Myocardial protection properties of parishins from the roots of Gastrodia elata Bl.
Identifieur interne : 000058 ( Main/Exploration ); précédent : 000057; suivant : 000059Myocardial protection properties of parishins from the roots of Gastrodia elata Bl.
Auteurs : Qi Wang [République populaire de Chine] ; Zhifeng Li [République populaire de Chine] ; Dongxu Wang [République populaire de Chine] ; Shinlin Yang [République populaire de Chine] ; Yulin Feng [République populaire de Chine]Source :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [ 1950-6007 ] ; 2020.
Descripteurs français
- KwdFr :
- Agents protecteurs (pharmacologie), Animaux (MeSH), Caspase-3 (métabolisme), Cytochromes c (métabolisme), Cytoplasme (effets des médicaments et des substances chimiques), Cytoplasme (métabolisme), Extraits de plantes (pharmacologie), Gastrodia (composition chimique), Ischémie myocardique (métabolisme), Ischémie myocardique (traitement médicamenteux), Lignée cellulaire (MeSH), Mitochondries (effets des médicaments et des substances chimiques), Mitochondries (métabolisme), Mitogen-Activated Protein Kinase 8 (métabolisme), Myocarde (métabolisme), Myocytes cardiaques (effets des médicaments et des substances chimiques), Myocytes cardiaques (métabolisme), Phosphorylation (effets des médicaments et des substances chimiques), Racines de plante (composition chimique), Rats (MeSH), Régulation négative (effets des médicaments et des substances chimiques), Régulation positive (effets des médicaments et des substances chimiques).
- MESH :
- composition chimique : Gastrodia, Racines de plante.
- effets des médicaments et des substances chimiques : Cytoplasme, Mitochondries, Myocytes cardiaques, Phosphorylation, Régulation négative, Régulation positive.
- métabolisme : Caspase-3, Cytochromes c, Cytoplasme, Ischémie myocardique, Mitochondries, Mitogen-Activated Protein Kinase 8, Myocarde, Myocytes cardiaques.
- pharmacologie : Agents protecteurs, Extraits de plantes.
- traitement médicamenteux : Ischémie myocardique.
- Animaux, Lignée cellulaire, Rats.
English descriptors
- KwdEn :
- Animals (MeSH), Caspase 3 (metabolism), Cell Line (MeSH), Cytochromes c (metabolism), Cytoplasm (drug effects), Cytoplasm (metabolism), Down-Regulation (drug effects), Gastrodia (chemistry), Mitochondria (drug effects), Mitochondria (metabolism), Mitogen-Activated Protein Kinase 8 (metabolism), Myocardial Ischemia (drug therapy), Myocardial Ischemia (metabolism), Myocardium (metabolism), Myocytes, Cardiac (drug effects), Myocytes, Cardiac (metabolism), Phosphorylation (drug effects), Plant Extracts (pharmacology), Plant Roots (chemistry), Protective Agents (pharmacology), Rats (MeSH), Up-Regulation (drug effects).
- MESH :
- chemical , metabolism : Caspase 3, Cytochromes c, Mitogen-Activated Protein Kinase 8.
- chemistry : Gastrodia, Plant Roots.
- drug effects : Cytoplasm, Down-Regulation, Mitochondria, Myocytes, Cardiac, Phosphorylation, Up-Regulation.
- drug therapy : Myocardial Ischemia.
- metabolism : Cytoplasm, Mitochondria, Myocardial Ischemia, Myocardium, Myocytes, Cardiac.
- chemical , pharmacology : Plant Extracts, Protective Agents.
- Animals, Cell Line, Rats.
Abstract
Parishins, important constituents of Gastrodia elata (G. elata), are known to exhibit a number of biological and pharmacological properties. However, their role and mechanisms of action in myocardial ischemia are unknown. The present study investigated the potential protective effects and mechanisms of parishins extracted from G. elata on hypoxia/reoxygenation (H/R) injury in H9c2 cardiomyocytes. The results demonstrated that parishins had significant protective effects on myocardial cells with parishins J and B providing greater cardioprotection through down-regulation of the level of cleaved-caspase-3 and cytochrome c in the cytoplasm and Bax, and up-regulation of cytochrome c in the mitochondria and Bcl-2 than induced by the positive control gastrodin. Additional study of the mechanisms of action indicated that the myocardial protection provided by parishin J was due to inhibition of JNK1 phosphorylation levels, down-regulation of c-jun and ATF-2 phosphorylation levels, a decrease in the phosphorylation of 14-3-3 and an increase in its binding to Bax. Therefore, parishin J was revealed to be a promising candidate as a novel treatment for myocardial protection.
DOI: 10.1016/j.biopha.2019.109645
PubMed: 31739164
Affiliations:
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Electronic address: lizhifeng1976@hotmail.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangxi University of Traditional Chinese Medicine, Nanchang 330002</wicri:regionArea><placeName><settlement type="city">Nanchang</settlement><region type="province">Jiangxi</region></placeName></affiliation></author><author><name sortKey="Wang, Dongxu" sort="Wang, Dongxu" uniqKey="Wang D" first="Dongxu" last="Wang">Dongxu Wang</name><affiliation wicri:level="1"><nlm:affiliation>Jiangxi University of Traditional Chinese Medicine, Nanchang 330002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangxi University of Traditional Chinese Medicine, Nanchang 330002</wicri:regionArea><placeName><settlement type="city">Nanchang</settlement><region type="province">Jiangxi</region></placeName></affiliation></author><author><name sortKey="Yang, Shinlin" sort="Yang, Shinlin" uniqKey="Yang S" first="Shinlin" last="Yang">Shinlin Yang</name><affiliation wicri:level="1"><nlm:affiliation>Jiangxi University of Traditional Chinese Medicine, Nanchang 330002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangxi University of Traditional Chinese Medicine, Nanchang 330002</wicri:regionArea><placeName><settlement type="city">Nanchang</settlement><region type="province">Jiangxi</region></placeName></affiliation></author><author><name sortKey="Feng, Yulin" sort="Feng, Yulin" uniqKey="Feng Y" first="Yulin" last="Feng">Yulin Feng</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Nanchang 330006, China. Electronic address: fengyulin2003@126.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Nanchang 330006</wicri:regionArea><placeName><settlement type="city">Nanchang</settlement><region type="province">Jiangxi</region></placeName></affiliation></author></analytic><series><title level="j">Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</title><idno type="eISSN">1950-6007</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Caspase 3 (metabolism)</term><term>Cell Line (MeSH)</term><term>Cytochromes c (metabolism)</term><term>Cytoplasm (drug effects)</term><term>Cytoplasm (metabolism)</term><term>Down-Regulation (drug effects)</term><term>Gastrodia (chemistry)</term><term>Mitochondria (drug effects)</term><term>Mitochondria (metabolism)</term><term>Mitogen-Activated Protein Kinase 8 (metabolism)</term><term>Myocardial Ischemia (drug therapy)</term><term>Myocardial Ischemia (metabolism)</term><term>Myocardium (metabolism)</term><term>Myocytes, Cardiac (drug effects)</term><term>Myocytes, Cardiac (metabolism)</term><term>Phosphorylation (drug effects)</term><term>Plant Extracts (pharmacology)</term><term>Plant Roots (chemistry)</term><term>Protective Agents (pharmacology)</term><term>Rats (MeSH)</term><term>Up-Regulation (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Agents protecteurs (pharmacologie)</term><term>Animaux (MeSH)</term><term>Caspase-3 (métabolisme)</term><term>Cytochromes c (métabolisme)</term><term>Cytoplasme (effets des médicaments et des substances chimiques)</term><term>Cytoplasme (métabolisme)</term><term>Extraits de plantes (pharmacologie)</term><term>Gastrodia (composition chimique)</term><term>Ischémie myocardique (métabolisme)</term><term>Ischémie myocardique (traitement médicamenteux)</term><term>Lignée cellulaire (MeSH)</term><term>Mitochondries (effets des médicaments et des substances chimiques)</term><term>Mitochondries (métabolisme)</term><term>Mitogen-Activated Protein Kinase 8 (métabolisme)</term><term>Myocarde (métabolisme)</term><term>Myocytes cardiaques (effets des médicaments et des substances chimiques)</term><term>Myocytes cardiaques (métabolisme)</term><term>Phosphorylation (effets des médicaments et des substances chimiques)</term><term>Racines de plante (composition chimique)</term><term>Rats (MeSH)</term><term>Régulation négative (effets des médicaments et des substances chimiques)</term><term>Régulation positive (effets des médicaments et des substances chimiques)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Caspase 3</term><term>Cytochromes c</term><term>Mitogen-Activated Protein Kinase 8</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Gastrodia</term><term>Plant Roots</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Gastrodia</term><term>Racines de plante</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cytoplasm</term><term>Down-Regulation</term><term>Mitochondria</term><term>Myocytes, Cardiac</term><term>Phosphorylation</term><term>Up-Regulation</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Myocardial Ischemia</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Cytoplasme</term><term>Mitochondries</term><term>Myocytes cardiaques</term><term>Phosphorylation</term><term>Régulation négative</term><term>Régulation positive</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cytoplasm</term><term>Mitochondria</term><term>Myocardial Ischemia</term><term>Myocardium</term><term>Myocytes, Cardiac</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Caspase-3</term><term>Cytochromes c</term><term>Cytoplasme</term><term>Ischémie myocardique</term><term>Mitochondries</term><term>Mitogen-Activated Protein Kinase 8</term><term>Myocarde</term><term>Myocytes cardiaques</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Agents protecteurs</term><term>Extraits de plantes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Plant Extracts</term><term>Protective Agents</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Ischémie myocardique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Rats</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Lignée cellulaire</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parishins, important constituents of Gastrodia elata (G. elata), are known to exhibit a number of biological and pharmacological properties. However, their role and mechanisms of action in myocardial ischemia are unknown. The present study investigated the potential protective effects and mechanisms of parishins extracted from G. elata on hypoxia/reoxygenation (H/R) injury in H9c2 cardiomyocytes. The results demonstrated that parishins had significant protective effects on myocardial cells with parishins J and B providing greater cardioprotection through down-regulation of the level of cleaved-caspase-3 and cytochrome c in the cytoplasm and Bax, and up-regulation of cytochrome c in the mitochondria and Bcl-2 than induced by the positive control gastrodin. Additional study of the mechanisms of action indicated that the myocardial protection provided by parishin J was due to inhibition of JNK1 phosphorylation levels, down-regulation of c-jun and ATF-2 phosphorylation levels, a decrease in the phosphorylation of 14-3-3 and an increase in its binding to Bax. Therefore, parishin J was revealed to be a promising candidate as a novel treatment for myocardial protection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31739164</PMID><DateCompleted><Year>2020</Year><Month>06</Month><Day>03</Day></DateCompleted><DateRevised><Year>2020</Year><Month>06</Month><Day>03</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1950-6007</ISSN><JournalIssue CitedMedium="Internet"><Volume>121</Volume><PubDate><Year>2020</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</Title><ISOAbbreviation>Biomed Pharmacother</ISOAbbreviation></Journal><ArticleTitle>Myocardial protection properties of parishins from the roots of Gastrodia elata Bl.</ArticleTitle><Pagination><MedlinePgn>109645</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0753-3322(19)35267-9</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.biopha.2019.109645</ELocationID><Abstract><AbstractText>Parishins, important constituents of Gastrodia elata (G. elata), are known to exhibit a number of biological and pharmacological properties. However, their role and mechanisms of action in myocardial ischemia are unknown. The present study investigated the potential protective effects and mechanisms of parishins extracted from G. elata on hypoxia/reoxygenation (H/R) injury in H9c2 cardiomyocytes. The results demonstrated that parishins had significant protective effects on myocardial cells with parishins J and B providing greater cardioprotection through down-regulation of the level of cleaved-caspase-3 and cytochrome c in the cytoplasm and Bax, and up-regulation of cytochrome c in the mitochondria and Bcl-2 than induced by the positive control gastrodin. Additional study of the mechanisms of action indicated that the myocardial protection provided by parishin J was due to inhibition of JNK1 phosphorylation levels, down-regulation of c-jun and ATF-2 phosphorylation levels, a decrease in the phosphorylation of 14-3-3 and an increase in its binding to Bax. Therefore, parishin J was revealed to be a promising candidate as a novel treatment for myocardial protection.</AbstractText><CopyrightInformation>Copyright © 2019 The Authors. Published by Elsevier Masson SAS.. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Qi</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Nanchang 330006, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Zhifeng</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Jiangxi University of Traditional Chinese Medicine, Nanchang 330002, China. Electronic address: lizhifeng1976@hotmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Dongxu</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Jiangxi University of Traditional Chinese Medicine, Nanchang 330002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Shinlin</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Jiangxi University of Traditional Chinese Medicine, Nanchang 330002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feng</LastName><ForeName>Yulin</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Nanchang 330006, China. Electronic address: fengyulin2003@126.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>11</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Biomed Pharmacother</MedlineTA><NlmUniqueID>8213295</NlmUniqueID><ISSNLinking>0753-3322</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020011">Protective Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-43-6</RegistryNumber><NameOfSubstance UI="D045304">Cytochromes c</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.24</RegistryNumber><NameOfSubstance UI="D048055">Mitogen-Activated Protein Kinase 8</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.22.-</RegistryNumber><NameOfSubstance UI="D053148">Caspase 3</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053148" MajorTopicYN="N">Caspase 3</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045304" MajorTopicYN="N">Cytochromes c</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003593" MajorTopicYN="N">Cytoplasm</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015536" MajorTopicYN="N">Down-Regulation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D031668" MajorTopicYN="N">Gastrodia</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008928" MajorTopicYN="N">Mitochondria</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D048055" MajorTopicYN="N">Mitogen-Activated Protein Kinase 8</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017202" MajorTopicYN="N">Myocardial Ischemia</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009206" MajorTopicYN="N">Myocardium</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032383" MajorTopicYN="N">Myocytes, Cardiac</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018517" MajorTopicYN="N">Plant Roots</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020011" MajorTopicYN="N">Protective Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015854" MajorTopicYN="N">Up-Regulation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Gastrodia elata</Keyword><Keyword MajorTopicYN="N">Myocardial ischemia</Keyword><Keyword MajorTopicYN="N">Parishins</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>06</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>10</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>11</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>11</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>6</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>11</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31739164</ArticleId><ArticleId IdType="pii">S0753-3322(19)35267-9</ArticleId><ArticleId IdType="doi">10.1016/j.biopha.2019.109645</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Jiangxi</li></region><settlement><li>Nanchang</li></settlement></list><tree><country name="République populaire de Chine"><region name="Jiangxi"><name sortKey="Wang, Qi" sort="Wang, Qi" uniqKey="Wang Q" first="Qi" last="Wang">Qi Wang</name></region><name sortKey="Feng, Yulin" sort="Feng, Yulin" uniqKey="Feng Y" first="Yulin" last="Feng">Yulin Feng</name><name sortKey="Li, Zhifeng" sort="Li, Zhifeng" uniqKey="Li Z" first="Zhifeng" last="Li">Zhifeng Li</name><name sortKey="Wang, Dongxu" sort="Wang, Dongxu" uniqKey="Wang D" first="Dongxu" last="Wang">Dongxu Wang</name><name sortKey="Yang, Shinlin" sort="Yang, Shinlin" uniqKey="Yang S" first="Shinlin" last="Yang">Shinlin Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|type= RBID
|clé= pubmed:31739164
|texte= Myocardial protection properties of parishins from the roots of Gastrodia elata Bl.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31739164" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a BiopestPeptidV1
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